![]() ![]() Jusqu'à présent, les efforts de recherche ont essentiellement porté sur la sécurité ainsi que sur la durée d action du médicament lorsqu administré par voie spinale. Contrairement à certains pays, la ROP n'est toujours pas indiquée au Canada pour la rachianesthésie (bloc central) en raison d'un manque de données probantes. La ropivacaïne (ROP), un AL à longue durée d action, est un médicament de première intention partout dans le monde, en raison de sa grande efficacité et de son faible risque de toxicité. 1 Université de Montréal Pharmacométrie de la ropivacaïne suivant l anesthésie locorégionale chez les patients orthopédiques : Caractérisation de l intensité et de la durée du bloc sensitif par François Gaudreault Faculté de pharmacie Thèse présentée à la Faculté de pharmacie en vue de l obtention du grade de Philosophiae Doctor en Sciences pharmaceutiques Avril 2013 François Gaudreault, 2013Ģ Résumé Introduction & Objectifs : Pour assurer l analgésie postopératoire, l anesthésiste dispose, en plus des différentes classes de médicaments administrés par voie orale ou intraveineuse, de diverses techniques pour bloquer l influx nerveux douloureux en administrant les anesthésiques locaux (AL) de manière centrale ou périphérique.
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